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Gestational Trophoblastic Disease




  • Informs on the clinical presentation of Gestational Trophoblastic Disease(GTD)
  • Discusses the management of GTD
  • Provides suggestions for how to live with GTD

Gestational trophoblastic disease (GTD) is a group of interrelated conditions originating from the chorionic portion of the placenta. The World Health Organization (WHO 1983) has classified GTD as consisting of:

  • two pre-malignant diseases - complete and partial hydatidiform mole; and
  • three malignant diseases - invasive mole, gestational, choriocarcinoma, and placental site trophoblastic tumour.

This chapter explores GTD; its incidence, diagnosis, management and more.


Contents include

  • Pathophysiology
    • GTD in general
    • Complete hydatidiform mole
    • Partial hydatidiform mole
    • Invasive mole
    • Choriocarcinoma
    • Placental site trophoblastic tumour
  • Incidence and risk factors
  • Clinical presentation
    • Complete and partial mole
    • Choriocarcinoma
    • PSTT
  • Diagnosis
    • Pre-malignant diseases
    • Malignant diseases
  • Management
    • Hydatidiform mole
    • Malignant gestational trophoblastic disease
    • Placental site trophoblastic tumour
    • Twin pregnancy
    • Follow-up
  • Living with gestational trophoblastic disease
    • Immediate consequences
    • Future pregnancies
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Author / Editor Biographies

Kathryn is a registered nurse who holds a bachelor's degree in science (nursing), a master's degree in medical science (palliative care), and a specialist practitioner qualification in palliative care. Kathryn has worked as a cancer nurse in Scotland and Australia for more than ten years and is currently the clinical nurse consultant for gynaecological oncology at the Sydney Cancer Centre. Kathryn has provided nursing representation on a variety of national working parties and has been involved in the development and implementation of guidelines for quality assurance, accreditation, and the ma...

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