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Cover image for lecture: Genetic Insights into Septic Shock

Lecture Overview

Septic shock is a serious and life-threatening complication of sepsis. Progressive organ failure can reduce life expectancy to less than three months in one-third of patients. This session considers how one’s genes may be linked to the development of septic shock and what this might mean for novel therapies.


Portrait of David Evans
David Evans

David Evans is a professor of statistical genetics and head of genomic medicine at the niversity of Queensland Diamantina Institute, and honorary professor at the Medical Research Council Integrative Epidemiology Unit at the University of Bristol. He completed his PhD in statistical genetics at the University of Queensland in 2003, before undertaking a four-year post-doctoral fellowship at the Wellcome Trust Centre for Human Genetics, University of Oxford. In 2007, he moved to take up a senior lecturer position at the University of Bristol, before returning in 2013 to Australia to take up his current position at the University of Queensland. David has published over 200 peer-reviewed articles, including several first and senior author publications in Nature and Nature Genetics. He has led the discovery of over 300 different genetic variants underlying common, complex traits and diseases, and has made major contributions to statistical genetic methods for gene mapping. In 2015, he and his collaborators were awarded a project grant from the Australian National Health and Medical Research Council to study the genetic and genomic basis of septic shock. The project, called the “ADRENAL GEPS” study, represents one of the largest genetic studies of sepsis ever performed. He and his colleagues are currently analysing the genomes of 570 patients suffering from septic shock and hope to present some preliminary results at the meeting and what they might mean for clinical care. See Educator Profile


12 Total Rating(s)
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Philippa marriott
16 Feb 2020

Education was really interesting

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Adrienne Hokin
15 Jan 2020

Interesting to hear how new information is gained for pharmacology research and into studying different disease.

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Andrea Easter
25 May 2019

Informative and easy to understand.

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Anna Carter
22 May 2019

Very technical about genetics. Not much clinical application

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Laura Chapman
17 Mar 2019

I felt that the lecturer was looking at information on his screen that I couldn't see. It would have been helpful in reinforcing what he was saying to be able to view this.

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Sue Marker
12 Mar 2019

Well presented.

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Debbie Mitschuinig
27 Feb 2019

Understand genetic factors influence my insight into suffering and or dying of septic shock in ICU. Genetic factors are important whether or not you end up in ICU with sepsis. Gene studies will assist in predicting if a drug will work or not. Therefore genetics will help or assist drug companies and assist in not wasting millions of dollars in developing a drug for testing knowing the drug will not actually work. The environment plays a part as well. Your genes you are stuck with, they come from your parents, cannot be changed.

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Suzanne Heale
27 Feb 2019

Very interesting information but not currently relevant to paramedicine.

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Penelope prema
27 Feb 2019

It wasn't exactly what I was expecting but interesting all the same. I would have liked to see the slides that he was showing the class members